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aminophylline + diphenhydramine
- Development stage
- Unknown
- Lead developer
- Scotmann Pharmaceuticals
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Scot's Expectorant is a combination pharmaceutical product developed by Scotmann Pharmaceuticals for the treatment of respiratory and allergic conditions. It contains aminophylline, a bronchodilator that works by relaxing bronchial smooth muscle through phosphodiesterase inhibition and adenosine receptor antagonism, and diphenhydramine, a first-generation antihistamine that acts as a competitive antagonist at the H1 receptor. This combination is typically used to alleviate symptoms associated with asthma, bronchitis, and allergic rhinitis where both bronchospasm and allergic inflammation are present. It is currently approved for use.
- Brand names
- Scot's Expectorant
- Other names
- Aminophyllin + Diphenhydramine
02
Targets
ADORA1 (Adenosine receptor A1 subtype)ADORA2A (Adenosine A₂A Receptor)ADORA2B (Adenosine A2B receptor)ADORA3 (Adenosine A3 receptor)HRH1 (Histamine H1 Receptor)M1 (Muscarinic acetylcholine receptor M1)PDE3/4 (Cyclic nucleotide phosphodiesterase 3 and 4)ADOR (Adenosine receptors)PDE (Phosphodiesterase family)
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