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Drug intelligence / Profile preview
aminophylline + methazolamide
- Development stage
- Phase 2
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Aminophylline + methazolamide is a combination of two small molecule drugs. Aminophylline is a nonselective adenosine receptor antagonist and phosphodiesterase inhibitor, primarily used as a bronchodilator for the treatment of asthma, chronic bronchitis, and emphysema. Methazolamide is a carbonic anhydrase inhibitor used mainly to treat glaucoma by reducing intraocular pressure but also has diuretic properties. The combination has been studied for its potential to abrogate hypoxia-mediated impairment in endurance exercise performance in humans, leveraging aminophylline’s respiratory stimulant effects and methazolamide’s ability to induce mild metabolic acidosis through carbonic anhydrase inhibition[1][6][7]. There are no widely recognized brand names or approved fixed-dose products containing both agents together.
- Other names
- methazolamide and aminophylline
02
Targets
ADOR (Adenosine receptors)CA1 (Carbonic anhydrase 1)CA2 (Carbonic Anhydrase 2)CA7 (Carbonic anhydrase VII)PDE (Phosphodiesterase family)CA4 (Carbonic anhydrase 4)
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