Drug intelligence / Profile preview

aminosilverlactone B mesylate

Development stage
Unknown
Lead developer
Jiangsu Kefeiping Pharmaceutical
Modality
Small Molecules
Administration
Intravenous
01

Overview

Aminosilverlactone B mesylate is a small molecule derivative of ginkgolide B, a natural terpene lactone found in *Ginkgo biloba*. Developed by Jiangsu Ke Feiping Pharmaceutical, the drug is designed as a potent platelet-activating factor (PAF) receptor antagonist for the treatment of acute ischemic stroke. By blocking the PAF receptor, it inhibits PAF-induced platelet aggregation, leukocyte activation, and inflammatory responses, which are key contributors to neuronal damage following an ischemic event. The drug is formulated as an injection for intravenous administration and has been evaluated in Phase 1 clinical trials for safety, tolerability, and pharmacokinetics.

Other names
aminoginkgolide B mesylate胺银内酯B甲磺酸盐甲磺酸胺银内酯B
02

Targets

PTAFR (Platelet-activating factor receptor)

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