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amitriptyline + chlordiazepoxide (Brilliant Lifesciences)
- Development stage
- Unknown
- Lead developer
- Brilliant Lifesciences
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
**Atri Plus** is a Brilliant Lifesciences oral fixed-dose generic formulation of the tricyclic antidepressant **amitriptyline** and the benzodiazepine anxiolytic **chlordiazepoxide**. The company lists two tablet strengths: amitriptyline hydrochloride 12.5 mg plus chlordiazepoxide 5 mg, and amitriptyline hydrochloride 25 mg plus chlordiazepoxide 10 mg. Amitriptyline inhibits serotonin and norepinephrine reuptake, while chlordiazepoxide positively modulates gamma-aminobutyric acid type A receptors; the combination is used for depressive symptoms accompanied by clinically significant anxiety.
- Brand names
- Atri Plus
02
Targets
HRH1 (Histamine H1 Receptor)NET (Norepinephrine Transporter)GABAA (Gamma-aminobutyric acid receptor)mAChR (Muscarinic acetylcholine receptors)ADRA1A (α1A)5-HT (Serotonin receptors)SERT (Sodium-dependent serotonin transporter)
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