amitriptyline + methylcobalamin

AmNurite S is an oral fixed-dose combination product developed by Health N U Therapeutics, containing the tricyclic antidepressant amitriptyline hydrochloride and the active vitamin B12 analogue methylcobalamin in a sustained-release formulation. Amitriptyline functions by inhibiting the reuptake of serotonin and norepinephrine at the synaptic cleft, which enhances descending inhibitory pain pathways in the spinal cord. Methylcobalamin acts as a cofactor for methionine synthase, playing a critical role in the methylation process required for the maintenance and regeneration of the myelin sheath. This dual-action approach is designed to provide symptomatic relief from neuropathic pain while supporting the structural repair of damaged peripheral nerves. It is typically utilized in the management of conditions such as diabetic neuropathy and postherpetic neuralgia.

Brand names

AmNurite SAmNurite 10/25AmNurite

Other names

Amitriptyline HCl and Methylcobalamin SR TabletsAmitriptyline HClMethylcobalamin