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Amlodez AT is a fixed-dose combination medication marketed by Emblazon Life Sciences, containing amlodipine and atenolol. Amlodipine is a long-acting dihydropyridine calcium channel blocker that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle, resulting in peripheral vasodilation and reduced blood pressure. Atenolol is a synthetic, beta-1 selective (cardioselective) adrenoreceptor blocking agent that reduces heart rate, cardiac output, and systolic and diastolic blood pressure. This combination is primarily indicated for the management of hypertension and chronic stable angina, where the dual mechanism of action provides synergistic effects in reducing myocardial oxygen demand and lowering systemic vascular resistance.
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