Drug intelligence / Profile preview

Amlodez AT

Development stage
Unknown
Lead developer
Johnlee Pharmaceuticals
Modality
Small Molecules
Administration
Oral
01

Overview

Amlodez AT is a fixed-dose combination medication marketed by Emblazon Life Sciences, containing amlodipine and atenolol. Amlodipine is a long-acting dihydropyridine calcium channel blocker that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle, resulting in peripheral vasodilation and reduced blood pressure. Atenolol is a synthetic, beta-1 selective (cardioselective) adrenoreceptor blocking agent that reduces heart rate, cardiac output, and systolic and diastolic blood pressure. This combination is primarily indicated for the management of hypertension and chronic stable angina, where the dual mechanism of action provides synergistic effects in reducing myocardial oxygen demand and lowering systemic vascular resistance.

Brand names
Amlodez AT
Other names
Amlodipine + AtenololAmlodipine and Atenolol combination
02

Targets

ADRB1 (β1)CACNA1C (Voltage-dependent L-type calcium channel subunit alpha-1C)

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