amlodipine + cilazapril + hydrochlorothiazide

Amlodipine + cilazapril + hydrochlorothiazide is a fixed-dose combination of three antihypertensive agents used for the treatment of high blood pressure (hypertension). Amlodipine is a calcium channel blocker that inhibits the influx of calcium ions into vascular smooth muscle and cardiac muscle, resulting in vasodilation and reduced blood pressure. Cilazapril is an angiotensin-converting enzyme (ACE) inhibitor that blocks the conversion of angiotensin I to angiotensin II, leading to vasodilation and decreased aldosterone-mediated sodium and water retention. Hydrochlorothiazide is a thiazide diuretic that increases renal excretion of sodium and water, further lowering blood pressure. The combination targets multiple mechanisms involved in hypertension for additive or synergistic effects[3][5][6].