Drug intelligence / Profile preview

Amlodipine + hydrochlorothiazide

Development stage
Unknown
Lead developer
Pfizer
Modality
Small Molecules
Administration
Oral
01

Overview

Amlodipine + hydrochlorothiazide is a fixed-dose combination of two antihypertensive agents used to treat high blood pressure (hypertension). Amlodipine is a calcium channel blocker that relaxes blood vessels and improves the efficiency of the heart in pumping blood. Hydrochlorothiazide is a thiazide diuretic that increases urine output by removing excess water and certain electrolytes from the body; over time it also helps relax blood vessels and improve blood flow. The combination provides additive effects for lowering blood pressure and reducing cardiovascular risk[5][8].

Brand names
Amlong-HAmlovas HStamlo DAsomex-DAmlokind-HAmlosafe HEspin HAmtas HTAdp HAmloz H
Other names
amlodipine + hydrochlorothiazide
02

Targets

SLC12A3 (Thiazide-sensitive sodium-chloride cotransporter)CACNA1C (Voltage-dependent L-type calcium channel subunit alpha-1C)

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