amlodipine + losartan potassium + hydrochlorothiazide

Amlodipine + losartan potassium + hydrochlorothiazide is a fixed-dose combination medication used primarily for the treatment of hypertension (high blood pressure). It combines three antihypertensive agents with complementary mechanisms: - **Amlodipine** is a calcium channel blocker that inhibits the influx of calcium ions into vascular smooth muscle and cardiac muscle. This action relaxes blood vessels and lowers blood pressure. - **Losartan potassium** is an angiotensin II receptor blocker (ARB) that blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking its binding to the AT1 receptor in many tissues. This leads to vasodilation and reduced blood pressure. - **Hydrochlorothiazide** is a thiazide diuretic that increases excretion of sodium and water by inhibiting sodium reabsorption in the distal tubules. This reduces plasma volume and decreases blood pressure. The combination provides additive antihypertensive effects through these distinct pathways. Lowering high blood pressure helps prevent strokes, heart attacks, heart failure, kidney failure, and other complications associated with chronic hypertension[1][2][5].

Brand names

Amlozaar-HTrilopaceAmlonis HNusar AmhResitan AmhAsomex LthAmlosar HCamlosar HDipress HLAdblock LH

Other names

amlodipine + losartan potassium + hydrochlorothiazide