amlodipine + rosuvastatin

Amlodipine + rosuvastatin is a fixed-dose combination drug containing two active pharmaceutical ingredients used for the management of patients with both hypertension and dyslipidemia. Amlodipine is an angioselective calcium channel blocker that inhibits the influx of calcium ions into vascular smooth muscle and cardiac muscle cells, resulting in vasodilation and reduced peripheral vascular resistance, thereby lowering blood pressure. Rosuvastatin is a selective HMG-CoA reductase inhibitor (statin) that lowers cholesterol by inhibiting the rate-limiting step in cholesterol biosynthesis, leading to decreased LDL-cholesterol levels and prevention of atherosclerosis. The combination addresses two major cardiovascular risk factors simultaneously—high blood pressure and high cholesterol—and has been shown to be more effective at reducing both systolic/diastolic blood pressure and LDL-C compared to either agent alone. It is primarily indicated for cardiovascular risk reduction in patients with concomitant hypertension and hypercholesterolemia[1][3][4][6].

Brand names

Rosuvam

Other names

rosuvastatin + amlodipine