amlodipine besylate + benazepril hydrochloride

Amlodipine besylate + benazepril hydrochloride is a fixed-dose combination oral medication used to treat high blood pressure (hypertension). It combines two antihypertensive agents with complementary mechanisms of action. Amlodipine is a dihydropyridine calcium channel blocker that inhibits the influx of calcium ions into vascular smooth muscle and cardiac muscle, resulting in vasodilation and reduced blood pressure. Benazepril is an angiotensin-converting enzyme (ACE) inhibitor that blocks the conversion of angiotensin I to angiotensin II, leading to vasodilation and decreased aldosterone-mediated water retention. The combination provides additive antihypertensive effects by targeting different pathways involved in blood pressure regulation[1][3][6]. The primary indication for this drug is the management of hypertension to reduce the risk of cardiovascular events such as stroke or heart attack[1][2][8].

Brand names

LotrelAmlobenz

Other names

amlodipine and benazeprilamlodipine and benazepril hydrochloride