AMLOPRIL

AMLOPRIL is a fixed-dose combination pharmaceutical product containing amlodipine and lisinopril, developed and distributed by GoodMed Healthcare for the management of hypertension. Amlodipine is a dihydropyridine calcium channel blocker that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle, leading to peripheral vasodilation and reduced blood pressure. Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor that prevents the conversion of angiotensin I to the potent vasoconstrictor angiotensin II. By inhibiting ACE, lisinopril reduces peripheral vascular resistance and decreases aldosterone secretion, which promotes sodium and water excretion. The combination of these two mechanisms provides a synergistic effect in lowering blood pressure and is used when monotherapy is insufficient.

Brand names

AMLOPRIL

Other names

amlodipine + lisinoprilAmlodipine 5 mg + Lisinopril 5 mg