Drug intelligence / Profile preview

ammonia + caffeine + chlorphenamine

Development stage
Unknown
Lead developer
Jinzhou Jiutai Pharmaceutical
Modality
Small Molecules
Administration
Oral
01

Overview

Ammonia + Caffeine + Chlorphenamine is an oral small molecule combination drug used to relieve symptoms of the common cold and influenza, such as fever, headache, nasal congestion, runny nose, and sneezing. Although 'ammonia' is a literal mistranslation of the Chinese character '氨' (An), the active antipyretic and analgesic component in this formulation is actually acetaminophen (paracetamol). The combination also includes caffeine, which acts as a central nervous system stimulant to enhance the analgesic effect and counteract drowsiness, and chlorphenamine (chlorpheniramine) maleate, a first-generation antihistamine that targets histamine H1 receptors to alleviate allergic-like cold symptoms. Some formulations also contain artificial cow-bezoar (Calculus Bovis) for its antipyretic and sedative properties. It is manufactured and marketed by various Chinese pharmaceutical companies, including Jinzhou Jiutai Pharmaceutical.

Other names
Ammonia Caffeine Chlorphenamine CapsulesAn Ka Huang MinAn Ka MinAnkahuangminAnkamin氨咖黄敏氨咖黄敏胶囊氨咖敏氨咖敏片
02

Targets

ADORA1 (Adenosine receptor A1 subtype)ADORA2A (Adenosine A₂A Receptor)HRH1 (Histamine H1 Receptor)PGHS-1 (Prostaglandin G/H Synthase 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)

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