Drug intelligence / Profile preview

ammonia + povidone-iodine + lidocaine hydrochloride + triamcinolone

Development stage
Unknown
Lead developer
Asclemed USA
Modality
Small Molecules
Administration
Intramuscular, Intraarticular, Inhalation, Topical
01

Overview

A multi-component prescription injection kit marketed as **Physician EZ Use Joint Tunnel and Trigger Kit** that combines **triamcinolone acetonide**, **lidocaine hydrochloride**, **povidone-iodine**, and **ammonia** for office-based musculoskeletal injection procedures. The therapeutic effect is primarily driven by triamcinolone acetonide, a synthetic glucocorticoid corticosteroid that activates the glucocorticoid receptor to suppress inflammatory gene expression and reduce local inflammation in intra-articular and soft-tissue conditions; lidocaine hydrochloride provides local anesthesia by blocking voltage-gated sodium channels and inhibiting nerve impulse conduction, while povidone-iodine serves as a topical antiseptic and ammonia is included as an inhalant component. The kit was marketed by Asclemed USA for intramuscular and intra-articular use contexts, but the product is described as an unapproved drug product whose labeling has not been approved by the FDA.

Brand names
Physician EZ Use Joint Tunnel and Trigger Kit
Other names
ammonia + povidone-iodine + lidocaine hydrochloride + triamcinolone
02

Targets

GR (Glucocorticoid receptor)NaV (Voltage-gated sodium channels)

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