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ammonium (15N) chloride
- Development stage
- Unknown
- Lead developer
- Children's Hospital of Philadelphia
- Modality
- Small Molecules
- Administration
- Oral, Intravenous
01
Overview
Ammonium (15N) chloride (15N-ammonium chloride) is a non-radioactive, stable isotope-labeled tracer used as a diagnostic agent to assess ureagenesis capacity and evaluate liver function, particularly in patients with urea cycle disorders (UCDs). By administering the tracer orally or enterally, researchers and clinicians can track the incorporation of the heavy nitrogen isotope (15N) into urea and amino acids (such as glutamine) in blood or urine using mass spectrometry. This allows for the non-invasive quantification of in vivo ureagenesis and the monitoring of therapeutic efficacy in metabolic disorders without the need for invasive liver biopsies.
- Other names
- 15N-ammonium chloride15N-labeled ammonium chloride15NH4Clammonium chloride-15Nammonium-15N chlorideammonium15N chlorideammonium 15N chloride
02
Targets
CPS1 (Carbamoyl phosphate synthetase I)GLUL (Glutamine synthetase)
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