Drug intelligence / Profile preview

AmnioFix

Development stage
Phase 4
Lead developer
MIMEDX
Administration
Intraarticular, Peri-tendinous, Soft Tissue Injection, Intra-lesional
01

Overview

AmnioFix is a proprietary tissue allograft composed of micronized dehydrated Human Amnion Chorion Membrane (mdHACM), developed by MiMedx Group. Derived from donated human placentas, the product is processed using the Purion® process to preserve the natural biological properties of the tissue, including a complex array of cytokines, growth factors, and interleukins. It is designed to act as a biologic scaffold and protective barrier to promote healing and reduce inflammation in musculoskeletal and surgical applications. Clinical development has focused on chronic inflammatory conditions such as plantar fasciitis, Achilles tendonitis, and knee osteoarthritis, as well as surgical uses in nerve protection and anastomotic leak prevention. The product is available both as a surgical sheet and as an injectable formulation.

Brand names
AmnioFixAmnioFix Injectable
Other names
micronized dehydrated Human Amnion Chorion MembranemdHACMdehydrated human amnion/chorion membranedHACMdehydrated human amniotic membraneDHAM
02

Targets

TGFB1 (Transforming growth factor Beta-1 proprotein)MMP12 (Macrophage Metalloelastase)IL8 (C-X-C Motif Chemokine Ligand 8)PDGF (Platelet-derived Growth Factor family)

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