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amniotic membrane stem cell telomerase enhanced implant
- Development stage
- Preclinical
- Lead developer
- Amnion Biosciences
- Modality
- Cell Therapies, Gene Therapies
- Administration
- Ophthalmic, Subretinal
01
Overview
The amniotic membrane stem cell telomerase enhanced implant is an experimental regenerative therapy consisting of mesenchymal stem cells derived from the amniotic membrane (AMSCs) that have been genetically modified to overexpress human telomerase reverse transcriptase (hTERT). This modification is designed to bypass replicative senescence, thereby extending the proliferative lifespan and maintaining the regenerative potency of the cells without inducing oncogenic transformation. These telomerase-enhanced cells are typically seeded onto a biological or synthetic scaffold, such as the amniotic membrane itself, to create a functional implant. The therapy aims to provide a sustained source of trophic factors, including anti-inflammatory cytokines and growth factors, to promote tissue repair and cellular replacement in degenerative conditions. Its primary development focus has been on ophthalmic indications, specifically for the treatment of geographic atrophy in age-related macular degeneration (AMD), where it is intended to support or replace damaged retinal pigment epithelium (RPE) cells.
- Other names
- hTERT-immortalized amniotic mesenchymal stem cell implanttelomerase-modified amniotic stem cell therapyhTERT-AMSC implant
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