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Drug intelligence / Profile preview
amoxicillin + dicloxacillin (Gujarat Medicraft)
- Development stage
- Unknown
- Lead developer
- Gujarat Medicraft
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Edilox DC is a fixed-dose combination of two beta-lactam antibiotics, amoxicillin (an aminopenicillin) and dicloxacillin (a penicillinase-resistant penicillin). It is developed by Medicraft (Gujarat Medicraft) and is approved in India for the treatment of various bacterial infections. Amoxicillin provides broad-spectrum antibacterial activity against Gram-positive and Gram-negative pathogens, while dicloxacillin is highly effective against penicillinase-producing staphylococci, thereby protecting amoxicillin from degradation by certain beta-lactamases and extending the overall spectrum of activity. Both components work synergistically by binding to penicillin-binding proteins (PBPs), inhibiting bacterial cell wall synthesis and leading to cell lysis.
- Brand names
- Edilox DCEdilox-DCEdilox-DC 500Edilox-DC500Edilox-DC-500
- Other names
- amoxicillin + dicloxacillinamoxycillin + dicloxacillinamoxycillin 250 + dicloxacillin 250
02
Targets
β-lactamasePBP1A (Penicillin-binding protein 1A)PBP4 (Penicillin-binding protein 4)
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