Drug intelligence / Profile preview

amoxicillin + ceftriaxone

Development stage: Preclinical
Lead developer: Roche
Modality: Small Molecules
Administration: Oral, Intravenous, Intramuscular

Overview

A combination of two antibiotics from different classes that demonstrates synergistic activity against bacterial infections, particularly penicillin-resistant Streptococcus pneumoniae. Amoxicillin is a penicillin-type antibiotic that inhibits bacterial cell wall synthesis, while ceftriaxone is a third-generation cephalosporin with broad-spectrum activity and a long half-life. The combination leverages complementary mechanisms to enhance antibacterial efficacy against resistant strains.

Targets

PBP (Penicillin-binding protein family)

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