Drug intelligence / Profile preview

amoxicillin + clarithromycin + esomeprazole

Development stage
Phase 4
Lead developer
AstraZeneca
Modality
Small Molecules
Administration
Oral
01

Overview

The combination of amoxicillin, clarithromycin, and esomeprazole is a triple therapy medication used primarily for the treatment of Helicobacter pylori (H. pylori) infection and associated peptic ulcers. This combination therapy is designed to eradicate the H. pylori bacteria while reducing stomach acid production to promote healing of ulcers. Amoxicillin is a penicillin-type antibiotic, clarithromycin is a macrolide antibiotic, and esomeprazole is a proton pump inhibitor (PPI). The antibiotics work together to kill the H. pylori bacteria, while esomeprazole reduces stomach acid to create an environment that allows the ulcers to heal and enhances the effectiveness of the antibiotics.

Brand names
Nexium Hp7Esomeprazole Sandoz Hp7a
Other names
amoxicillin + clarithromycin + esomeprazoleclarithromycin + esomeprazole + amoxicillin
02

Targets

Bacterial 50S ribosomal subunitATP4A (Potassium–transporting ATPase alpha chain 1)PBP (Penicillin-binding protein family)

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