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amoxicillin + clavulanate
- Development stage
- Approved
- Lead developer
- GSK
- Modality
- Small Molecules
- Administration
- Oral, Intravenous
01
Overview
Amoxicillin + clavulanate is a combination antibiotic consisting of two active ingredients: amoxicillin, a penicillin-class beta-lactam antibiotic, and clavulanate (clavulanic acid), a beta-lactamase inhibitor. Amoxicillin works by inhibiting bacterial cell wall synthesis, leading to bacterial death. However, some bacteria produce beta-lactamase enzymes that can inactivate amoxicillin. Clavulanate inhibits these enzymes, thereby protecting amoxicillin from degradation and extending its spectrum of activity against resistant bacteria. This combination is used to treat various bacterial infections including those of the ear, lungs (such as pneumonia and bronchitis), sinuses, skin, urinary tract, and animal bites[1][2][3][5]. It is available in oral and intravenous formulations.
- Brand names
- AugmentinAugmentin ES-600Augmentin XRAmoclanAlti-Amoxi ClavApo-Amoxi ClavNovo-Clavamoxin 125Novo-Clavamoxin125Novo-Clavamoxin-125Novo-Clavamoxin 250Novo-Clavamoxin250Novo-Clavamoxin-250Ratio-Amoxi Clav 250
- Other names
- amoxicillin/clavulanic acidco-amoxiclavamox-clav
02
Targets
PBP (Penicillin-binding protein family)β-lactamase
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