Drug intelligence / Profile preview

Amoxicillin + doxycycline

Development stage
Unknown
Lead developer
GSK
Modality
Small Molecules
Administration
Oral, Topical
01

Overview

**Amoxicillin + doxycycline** is a combination of two antibiotics from different classes: amoxicillin, a penicillin-type antibiotic, and doxycycline, a tetracycline antibiotic. Amoxicillin acts as a bactericidal agent by inhibiting bacterial cell wall synthesis, leading to cell lysis and death. Doxycycline is bacteriostatic and inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, preventing the addition of amino acids to polypeptide chains. Both drugs are used individually for various bacterial infections; however, their combined use is generally avoided because tetracyclines like doxycycline can reduce the effectiveness of penicillin-type antibiotics such as amoxicillin. This combination may be considered in rare clinical scenarios but is not standard practice due to potential antagonism between the drugs[1][2][3][8].

Brand names
VibramycinAtridoxActiclate CapDoxtericDoxy
02

Targets

PBP (Penicillin-binding protein family)30S A-site (Bacterial ribosomal 30S A-site)

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