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amoxicillin + ibuprofen + hydrocodone + acetaminophen
- Development stage
- Unknown
- Lead developer
- University of Michigan
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
This combination regimen is a supportive pharmacological protocol utilized in clinical trials at the University of Michigan for patients undergoing dental procedures related to alveolar bone loss and tooth loss, specifically during immediate implant placement. The regimen consists of amoxicillin, a beta-lactam antibiotic that prevents post-operative infection by inhibiting bacterial cell wall synthesis through binding to penicillin-binding proteins; ibuprofen, a non-steroidal anti-inflammatory drug (NSAID) that reduces pain and inflammation by inhibiting cyclooxygenase enzymes (COX-1 and COX-2); and Vicodin, a combination of the mu-opioid receptor agonist hydrocodone and the analgesic acetaminophen. This multi-modal approach is designed to manage infection risk and provide comprehensive pain control following tooth extraction and guided bone regeneration procedures.
- Brand names
- Vicodin
- Other names
- Medications-University of Michigan-alveolar bone loss-tooth lossUniversity of Michigan dental medication protocolAmoxicillin/Ibuprofen/Vicodin regimen
02
Targets
PTGS2 (Prostaglandin-Endoperoxide Synthase 2)MOR (Mu opioid receptor)PGHS-1 (Prostaglandin G/H Synthase 1)PBP (Penicillin-binding protein family)
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