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amoxicillin + levofloxacin + vonoprazan fumarate
- Development stage
- Preclinical
- Lead developer
- Phathom Pharmaceuticals
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
A combination therapy consisting of amoxicillin (antibiotic), levofloxacin (antibiotic), and vonoprazan fumarate (potassium-competitive acid blocker) used for the treatment of Helicobacter pylori infection. This combination leverages vonoprazan's potent acid suppression capabilities, which are stronger than traditional proton pump inhibitors, along with two antibiotics to effectively eradicate H. pylori bacteria, particularly in cases where antibiotic resistance may be a concern.
- Other names
- Vonoprazan + Levofloxacin-Based Triple TherapyCURE-H. Pylori Arm 3
02
Targets
ATP4A (Potassium–transporting ATPase alpha chain 1)Topo IV (Bacterial Topoisomerase IV)DNA gyrasePBP (Penicillin-binding protein family)
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