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amoxicillin + omeprazole
- Development stage
- Unknown
- Lead developer
- RedHill Biopharma
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Amoxicillin + omeprazole is a combination of two pharmaceutical agents used primarily in the treatment of infections caused by Helicobacter pylori, particularly in the context of peptic ulcer disease. Amoxicillin is a penicillin-class antibiotic that inhibits bacterial cell wall synthesis, leading to bacterial death. Omeprazole is a proton pump inhibitor (PPI) that suppresses gastric acid secretion by irreversibly inhibiting the H+/K+ ATPase enzyme system at the secretory surface of gastric parietal cells. This reduction in stomach acidity enhances the effectiveness of antibiotics like amoxicillin against H. pylori and promotes ulcer healing.
- Brand names
- Prilosec
- Other names
- amoxicillin/omeprazoleH. pylori treatment regimenShandong Intervention Trial intervention
02
Targets
PBP (Penicillin-binding protein family)ATP4A (Potassium–transporting ATPase alpha chain 1)
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