Drug intelligence / Profile preview

amoxicillin + paracetamol

Development stage
Unknown
Lead developer
GSK
Modality
Small Molecules
Administration
Oral
01

Overview

Amoxicillin + paracetamol is a fixed-dose or co-administered combination of a broad-spectrum penicillin antibiotic and a non-opioid analgesic/antipyretic. Amoxicillin, a beta-lactam antibiotic, acts by inhibiting bacterial cell wall synthesis through binding to penicillin-binding proteins (PBPs), which leads to bacterial lysis and death. Paracetamol (acetaminophen) provides analgesic and antipyretic effects, primarily through the inhibition of cyclooxygenase (COX) enzymes in the central nervous system and modulation of endogenous cannabinoid and serotonergic pathways. This combination is typically indicated for the management of bacterial infections accompanied by pain or fever, such as dental abscesses, otitis media, or respiratory tract infections, where symptomatic relief is required alongside antimicrobial therapy.

Brand names
AmoxiparaAmoparAmoxmolAmoxipainZimox + Tachipirina
Other names
amoxicillin and paracetamolamoxicillin/paracetamolamoxicillin and acetaminophen
02

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)PGHS-1 (Prostaglandin G/H Synthase 1)PBP (Penicillin-binding protein family)

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