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amphetamine salt combo XR + topiramate
- Development stage
- Unknown
- Lead developer
- Elite Pharmaceuticals
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
A combination therapy consisting of extended-release mixed amphetamine salts (Adderall XR) and topiramate. This combination has been studied primarily for the treatment of cocaine use disorder. The proposed mechanism involves normalizing dopamine signaling by both increasing baseline dopamine transmission (via amphetamine) and reducing cocaine-induced dopamine release (via topiramate). Clinical trials have shown this combination to be efficacious in promoting abstinence in cocaine-dependent individuals, particularly those with high baseline frequency of cocaine use.
- Brand names
- Adderall XR + Topamax
- Other names
- mixed amphetamine salts extended-release + topiramateMAS-ER + topiramate
02
Targets
DAT (Dopamine plasma membrane transport protein)NaV (Voltage-gated sodium channels)TAAR1 (Trace amine-associated receptor 1)NET (Norepinephrine Transporter)GRIK1 (Glutamate ionotropic receptor kainate type subunit 1)VMAT2 (Vesicular monoamine transporter 2)AMPAR (AMPA receptor)GABRR (GABA-A receptor subunit rho)CA2 (Carbonic Anhydrase 2)
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