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amphetamine salt combo XR + topiramate
- Development stage
- Unknown
- Lead developer
- Elite Pharmaceuticals
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
A combination therapy consisting of extended-release mixed amphetamine salts (Adderall XR) and topiramate. This combination has been studied primarily for the treatment of cocaine use disorder. The proposed mechanism involves normalizing dopamine signaling by both increasing baseline dopamine transmission (via amphetamine) and reducing cocaine-induced dopamine release (via topiramate). Clinical trials have shown this combination to be efficacious in promoting abstinence in cocaine-dependent individuals, particularly those with high baseline frequency of cocaine use.
- Brand names
- Adderall XR + Topamax
- Other names
- mixed amphetamine salts extended-release + topiramateMAS-ER + topiramate
02
Targets
AMPAR (AMPA receptor)CA2 (Carbonic Anhydrase 2)DAT (Dopamine plasma membrane transport protein)GABRR (GABA-A receptor subunit rho)GRIK1 (Glutamate ionotropic receptor kainate type subunit 1)NET (Norepinephrine Transporter)TAAR1 (Trace amine-associated receptor 1)VMAT2 (Vesicular monoamine transporter 2)NaV (Voltage-gated sodium channels)iGluR (Ionotropic receptor 76b (Ir76b))GABA-B (Gamma-aminobutyric acid receptor type B)
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