amphomycin

Amphomycin is a natural antibacterial lipopeptide antibiotic produced by the bacterium Streptomyces canus. It is a cyclic depsipeptide with a peptidyl side chain capped by a saturated alkyl tail. Amphomycin preferentially targets Gram-positive bacteria and has shown activity against drug-resistant strains. Its primary mechanism of action is inhibition of bacterial cell wall synthesis through blocking the enzyme phospho-N-acetylmuramoyl-pentapeptide-transferase (MraY/translocase I), which is essential for peptidoglycan biosynthesis in bacteria. Amphomycin was first reported in 1953 by researchers at Bristol-Myers and has been used as an antibiotic in veterinary medicine[1][3][4][5][7].

Other names

amfomycinamfomycineamfomycinumanfomicinaglumamycincrystallomycinkrystallomycinzaomycin