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Amphotericin B liposome
- Development stage
- Approved
- Lead developer
- Gilead Sciences
- Modality
- Recombinant Proteins and Enzymes, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
Amphotericin B liposome is a lipid-based formulation of the antifungal agent amphotericin B. It is used intravenously to treat serious and life-threatening fungal infections, including cryptococcal meningitis (especially in HIV-infected patients), leishmaniasis, and other invasive fungal diseases[1][2][8]. The drug consists of amphotericin B intercalated within a unilamellar bilayer liposomal membrane composed of phospholipids and cholesterol[4]. This formulation improves the safety profile compared to conventional amphotericin B by reducing nephrotoxicity while maintaining efficacy[5]. The mechanism of action involves binding to ergosterol in the fungal cell membrane, forming pores that disrupt membrane integrity and cause leakage of cellular contents leading to cell death[5][6]. AmBisome is the most widely recognized brand name for this formulation.
- Brand names
- AmBisome
- Other names
- amphotericin B liposomalliposomal amphotericin BLAmB
02
Targets
Ergosterol
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