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amphotericin B phosphatidylglycerol complex liposome
- Development stage
- Phase 1
- Lead developer
- Beijing Tide Pharmaceutical
- Modality
- Small Molecules, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
Amphotericin B phosphatidylglycerol complex liposome is an investigational liposomal formulation of the polyene antifungal amphotericin B, developed by Beijing Tide Pharmaceutical. The drug functions by binding to ergosterol, a key component of fungal cell membranes, which leads to the formation of transmembrane pores. These pores cause the leakage of essential intracellular ions and molecules, ultimately resulting in fungal cell death. This specific formulation utilizes a phosphatidylglycerol complex within a liposomal structure to optimize the pharmacokinetic profile and reduce the nephrotoxicity typically associated with conventional amphotericin B deoxycholate. It is being evaluated in clinical trials for the treatment of systemic fungal infections, leishmaniasis, and as empirical therapy for suspected fungal infections in patients with febrile neutropenia.
- Other names
- amphotericin B phosphatidylglycerol complex liposome injectionamphotericin B liposome
02
Targets
Ergosterol
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