amylocaine

Amylocaine is a synthetic local anesthetic that was the first of its kind, synthesized and patented under the name Stovaine by Ernest Fourneau at the Pasteur Institute in 1903. It was primarily used for spinal anesthesia, especially in procedures such as Caesarean sections. Amylocaine acts as a membrane-stabilizing agent by reversibly binding to and blocking voltage-gated sodium channels in excitable membranes of sensory neurons. This blockade inhibits sodium influx necessary for action potential generation and nerve impulse conduction, thereby preventing pain signal transmission during surgical procedures. Although it was developed as a safer alternative to cocaine for regional anesthesia, amylocaine has largely been replaced by newer agents due to limitations in efficacy and safety profile[1][5][6].

Brand names

StovaineForneaucaine

Other names

amylocaine hydrochloride