AN-2718

AN-2718 is a small molecule antifungal drug belonging to the benzoxaborole class. It acts by inhibiting fungal protein synthesis through selective inhibition of leucyl-tRNA synthetase (LeuRS), using the oxaborole tRNA trapping (OBORT) mechanism. This results in blocking protein synthesis and halting fungal growth. AN-2718 was developed for topical treatment of tinea pedis, including hard-to-treat moccasin-type infections that are typically only responsive to oral antifungals. The compound demonstrated broad-spectrum antifungal activity in vitro against dermatophytes such as Trichophyton rubrum and Trichophyton mentagrophytes, as well as Candida species and Aspergillus fumigatus[2][3][5][6]. Development for this indication has been discontinued.

Other names

5-chloro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole