Drug intelligence / Profile preview

Anaerostipes caccae

Development stage
Unknown
Lead developer
Clostrabio
Modality
Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration
Oral
01

Overview

*Anaerostipes caccae* is a next-generation probiotic and live biotherapeutic product consisting of a specific strain of lactate-utilizing, butyrate-producing anaerobic bacteria. Developed by Clostrabio (as CLB101), it is designed to restore gut microbiome balance and metabolic functions, specifically butyrogenesis. In the context of food allergies and inflammatory conditions like ulcerative colitis, it acts by cross-feeding with lactic acid bacteria (such as *Weizmannia coagulans*) to convert lactate into butyrate. Butyrate is a critical short-chain fatty acid that supports intestinal barrier integrity and modulates immune responses. The product is positioned as a dietary supplement for gut microbiome support in infants and adults with food allergies and dysbiosis.

Brand names
CLB101CLB-101CLB 101
Other names
Anaerostipes caccae

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