Anaerostipes rhamnosivorans

**Anaerostipes rhamnosivorans** is a live biotherapeutic bacterium isolated from the stool of a healthy 1-year-old Dutch infant. It is a Gram-variable, strictly anaerobic, spore-forming, butyrate-producing bacterium belonging to the genus Anaerostipes within the family Lachnospiraceae. This bacterium is characterized by its curly rod-shaped morphology and its ability to produce beneficial short-chain fatty acids (SCFAs), particularly butyrate, propionate, and acetate. **Metabolic Capabilities:** A. rhamnosivorans performs mixed acid fermentations with various sugars, including the unique ability to ferment rhamnose to butyrate, a feature not commonly found in other intestinal microbes. The bacterium can produce butyrate from sugars as well as from lactate plus acetate. It can also convert myo-inositol and chiro-inositol into propionate and acetate through a specialized metabolic pathway involving 3-oxoacid CoA transferase. **Mechanism of Action:** The therapeutic effects are attributed to the production of beneficial metabolites, particularly butyrate and propionate. Butyrate is essential for maintaining intestinal barrier function and colon health. The bacterium's ability to convert dietary myo-inositol into propionate and acetate may contribute to improved glucose metabolism. Studies have shown that live A. rhamnosivorans, when co-administered with myo-inositol, can reduce fasting glucose levels in mice fed a western diet. **Development:** Research is being conducted on A. rhamnosivorans as a potential live biotherapeutic for metabolic syndrome and type 2 diabetes, with studies demonstrating negative correlations between propionate production gene clusters and metabolic disease biomarkers such as fasting insulin and serum triglycerides.

Other names

A. rhamnosivoransARHAMstrain 1y-2strain1y-2strain-1y-2DSM 26241DSM26241DSM-26241KCTC 15316KCTC15316KCTC-15316