anastrozole + leuprolide

anastrozole + leuprolide is a combination therapy investigated for the treatment of endometriosis recurrence. Anastrozole is a potent, non-steroidal aromatase inhibitor that reduces estrogen levels by inhibiting the enzyme responsible for converting androgens into estrogens in peripheral tissues and within endometriotic lesions. Leuprolide acetate is a gonadotropin-releasing hormone (GnRH) agonist that induces a state of hypogonadotropic hypogonadism, thereby suppressing ovarian estrogen production. The combination of these two agents aims to achieve a more complete suppression of estrogen—both from the ovaries and from peripheral or local sources—than GnRH agonists alone, potentially improving outcomes for patients with recurrent endometriosis. This specific therapeutic approach was evaluated in a Phase 4 clinical trial sponsored by the Centre for Endocrinology and Reproductive Medicine in Italy.

Brand names

ArimidexLupron

Other names

anastrazole + luprolideanastrozole + leuprolide acetateanastrazole + leuprolide