anastrozole + PEGylated liposomes

Anastrozole + PEGylated liposomes is an experimental nanomedicine formulation in which anastrozole, a third-generation non-steroidal aromatase inhibitor of the triazole class, is encapsulated within PEGylated (sterically stabilized, long-circulating) liposomes. The active ingredient, anastrozole, targets the aromatase enzyme to suppress estrogen biosynthesis, which is a key therapeutic strategy for hormone-dependent breast cancer. The PEGylated liposomal delivery system is designed to extend circulation time, improve oral bioavailability, and enhance tumor growth inhibition compared to conventional liposomes or the free drug. In vitro studies have demonstrated greater cytotoxic activity against BT-549 and MCF-7 breast cancer cell lines, and pharmacokinetic studies in Wistar rats showed a ~20-fold increase in drug exposure (AUC) relative to pure anastrozole.

Other names

PEGylated liposomal anastrozolePEGylated liposomes of anastrozoleanastrozole PEGylated liposomes