andrographis paniculata + withania somnifera

This is a **combination of two herbal extracts:**\n- **Andrographis paniculata** ("king of bitters") is a plant used in traditional medicine, known for its anti-inflammatory, immunomodulatory, and antioxidant properties. Its primary bioactive compound is andrographolide, which has demonstrated anti-stress, anti-inflammatory, and immune regulatory effects in preclinical and limited clinical studies.\n- **Withania somnifera** ("ashwagandha") is an adaptogenic herb widely used in Ayurveda and traditional Indian medicine for stress reduction, enhancement of physical and mental performance, and immune modulation. Its main active constituents are withanolides.\nThe combination is used as an **adaptogenic** and **anti-stress** formulation, aiming to support resilience to stress, modulate immune and inflammatory responses, and mitigate some pathophysiological consequences of chronic stress. There is limited but emerging research, including at least one registered randomized placebo-controlled trial, on this specific combination in adaptogenic and anti-stress indications[5][1][7]. The principal mechanism for both ingredients involves the modulation of cytokine production and the hypothalamic-pituitary-adrenal (HPA) axis, with effects on cortisol/corticosterone and pro- and anti-inflammatory cytokines such as TNF-α, IL-1β, and IL-10[1].

Other names

andrographis + ashwagandhaandrographis and ashwagandhaashwagandha + andrographis