Drug intelligence / Profile preview

andrographis paniculata extract

Development stage
Unknown
Lead developer
Himalaya Wellness Company
Modality
Small Molecules
Administration
Oral
01

Overview

Andrographis paniculata extract is a herbal preparation derived from the plant Andrographis paniculata (family Acanthaceae), commonly known as "King of Bitters." The primary active compound in the extract is andrographolide—a diterpene lactone—along with other diterpenoids and flavonoids. Traditionally used in Ayurvedic and Chinese medicine as an immunostimulant and antipyretic agent[1][3][5], it has been clinically studied for its potential anti-inflammatory[1][5], antiviral[8], antibacterial[5], immunomodulatory[8], and antipyretic activities. Research suggests that its mechanism involves reducing pro-inflammatory cytokines to exert anti-inflammatory effects[5]. It has been investigated for use in respiratory tract infections (such as the common cold), osteoarthritis[1], hypertriglyceridemia[1], inflammatory bowel disease[4], and other inflammatory conditions. However, robust clinical evidence supporting these uses remains limited.

Brand names
Chuanxinlian Capsules
Other names
AndrographisAluiBhui-neemBhunimbaChuan Xin LianChuanxinlianCreatGreen chiretaKalmeghKalmeghaKing of bittersKirayatMahatitaNemone chinensiSam bilotoYavatikta
02

Targets

FASN (Fatty acid synthase)PXR (Pregnane X receptor)CXADR (Coxsackievirus and adenovirus receptor)

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