Drug intelligence / Profile preview

andrographis paniculata leaf extract

Development stage
Unknown
Lead developer
University of Southampton
Modality
Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
Administration
Oral
01

Overview

Andrographis paniculata leaf extract is a botanical medicine derived from the *Andrographis paniculata* plant, traditionally used in Ayurvedic and Chinese medicine. Its primary active constituents are andrographolides, which exhibit anti-inflammatory, antiviral, and immune-stimulatory properties. The extract is being evaluated as a non-antibiotic symptomatic treatment for acute respiratory tract infections (ARTIs), including cough and sore throat, to help reduce unnecessary antibiotic prescribing and combat antimicrobial resistance. Clinical research, such as the feasibility study led by the University of Southampton in collaboration with the NIHR School for Primary Care Research, focuses on its efficacy in managing symptoms of common colds and acute respiratory infections by modulating immune responses and inhibiting inflammatory signaling pathways.

Other names
Chuān Xīn LiánKing of BittersKalmeghAndrographis paniculata extract
02

Targets

IL-6 (Interleukin 6)

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