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Andrographis paniculata leaf extract is a botanical medicine derived from the *Andrographis paniculata* plant, traditionally used in Ayurvedic and Chinese medicine. Its primary active constituents are andrographolides, which exhibit anti-inflammatory, antiviral, and immune-stimulatory properties. The extract is being evaluated as a non-antibiotic symptomatic treatment for acute respiratory tract infections (ARTIs), including cough and sore throat, to help reduce unnecessary antibiotic prescribing and combat antimicrobial resistance. Clinical research, such as the feasibility study led by the University of Southampton in collaboration with the NIHR School for Primary Care Research, focuses on its efficacy in managing symptoms of common colds and acute respiratory infections by modulating immune responses and inhibiting inflammatory signaling pathways.
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