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anfeihewei
- Development stage
- Unknown
- Lead developer
- Changzhou Yinsheng Pharmaceutical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Anfeihewei is a novel small molecule direct-acting antiviral (DAA) agent developed by Changzhou Yinsheng Pharmaceutical for the treatment of chronic hepatitis C virus (HCV) infection. It functions as an inhibitor of the HCV NS3/4A protease, an essential enzyme for the viral replication cycle that cleaves the viral polyprotein into functional proteins. Anfeihewei is specifically being developed for patients with genotype 1 chronic hepatitis C. In clinical trials, it has been evaluated both as a monotherapy to assess its safety and pharmacokinetics and in combination with other DAAs, such as sofosbuvir, to enhance antiviral efficacy. The drug is currently in Phase 2 clinical development in China, representing a part of the domestic effort to develop effective, all-oral treatment regimens for HCV.
- Other names
- 安非合韦Anfeihewei Soft Capsules
02
Targets
NS3/4A (Hepatitis C virus nonstructural protein 3/4A serine protease)
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