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ANG1009
- Development stage
- Preclinical
- Lead developer
- Angiochem
- Modality
- Peptide-Drug Conjugates → Peptide Conjugates → Peptides, Small Molecules
- Administration
- Intravenous
01
Overview
ANG1009 is a preclinical peptide-drug conjugate (PDC) developed by Angiochem for the treatment of brain cancer. It utilizes Angiochem's proprietary EPiC (Engineered Peptide Compounds) platform, specifically the Angiopep-2 peptide, which is designed to cross the blood-brain barrier (BBB) by targeting the low-density lipoprotein receptor-related protein 1 (LRP1) via receptor-mediated transcytosis. The therapeutic payload is etoposide, a chemotherapy agent that inhibits DNA topoisomerase II, leading to double-stranded DNA breaks and cell death. By conjugating etoposide to the Angiopep-2 carrier, ANG1009 aims to overcome the poor CNS penetration of conventional etoposide, potentially providing a more effective treatment for primary brain tumors and brain metastases.
02
Targets
TOP2A (DNA topoisomerase II)LRP1 (Prolow-density lipoprotein receptor-related protein 1)
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