Drug intelligence / Profile preview

angelica sinensis + radix arnebiae seu lithospermi

Development stage
Preclinical
Modality
Small Molecules
Administration
Topical, Oral
01

Overview

This is a combination of two traditional herbal medicines widely used in East Asian medicine: - **Angelica sinensis** (commonly known as dong quai or Chinese angelica) is the root of a plant traditionally used for female health concerns such as menstrual disorders and menopausal symptoms. Its main bioactive compounds include ligustilide and various polysaccharides. It has demonstrated anti-inflammatory, antispasmodic, vasodilatory, estrogenic-like, antioxidant, and possible antitumor activities in preclinical studies. The mechanism may involve modulation of inflammatory cytokines and inhibition of COX-2 enzyme activity[1][3][4][5]. - **Radix arnebiae seu lithospermi** refers to the dried roots of Arnebia euchroma or Lithospermum erythrorhizon (commonly called "zicao" or "purple gromwell"). This herb is traditionally used for its anti-inflammatory, wound healing, antimicrobial, and skin-protective properties due to active compounds like shikonin. The combination is not an approved pharmaceutical drug but rather a traditional herbal formulation often found in topical preparations for skin conditions (such as burns or eczema), gynecological uses (menstrual regulation), or general tonic purposes. There are no large-scale clinical trials confirming efficacy; use remains based on traditional practice.

Other names
dong quai + zicaoangelica root + lithospermum rootdang gui + zi cao
02

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)ER (Estrogen receptor)

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