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Angong Niuhuang Pill

Development stage: Phase 3
Lead developer: Huqing Yutang
Modality: Small Molecules
Administration: Oral, Nasogastric

Overview

Angong Niuhuang Pill is a traditional Chinese patent medicine with a history dating back to the Qing Dynasty, first described in the medical text "Treatise on Differentiation and Treatment of Epidemic Febrile Diseases" by Wu Jutong. It consists of 11 medicinal ingredients including Bovis Calculus, Powdered Buffalo Horn Extract, Artificial Moschus, Margarita, Cinnabaris, Realgar, Coptidis Rhizoma, Scutellariae Radix, Gardeniae Fructus, Curcumae Radix, and Borneolum Syntheticum. The formula is known for its antipyretic, anti-inflammatory, anticonvulsant, sedative, and neuroprotective properties. Modern pharmacological research has demonstrated its efficacy in treating various central nervous system conditions including stroke, coma, viral encephalitis, and traumatic brain injury. It has been shown to reduce cerebral infarct and edema volumes, improve neurological function, and promote recovery in comatose patients.

Brand names: Angong Niuhuang Wan
Other names: Angong Niuhuang Wan

Targets

IL-6 (Interleukin 6)FOXO3 (Forkhead box protein O3)PIK3CA (Phosphoinositide 3-kinase alpha)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)HIF1A (Hypoxia-inducible factor 1-alpha)MAPK3 (Mitogen-activated protein kinase 1)

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