Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
angong niuhuang wan
- Development stage
- Unknown
- Lead developer
- Fudan University
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral, Sublingual
01
Overview
Angong Niuhuang Pill (ANP) is a classic Traditional Chinese Medicine (TCM) formula widely utilized for the emergency treatment of acute cerebrovascular diseases, including ischemic and hemorrhagic stroke, as well as other conditions involving high fever, coma, and convulsions. The formula traditionally consists of eleven ingredients: Calculus Bovis (cow bezoar), Cornu Bubali (water buffalo horn), Moschus (musk), Margarita (pearl), Cinnabaris (cinnabar), Realgar, Rhizoma Coptidis, Radix Scutellariae, Fructus Gardeniae, Radix Curcumae, and Borneolum Syntheticum. In the context of the **APEX-STROKE** trial led by **Fudan University**, the "Early" designation refers to a specific clinical protocol evaluating the hyper-acute administration of the drug, including pre-hospital sublingual suspension delivery in ambulances. ANP is hypothesized to exert neuroprotective effects by mitigating neuroinflammation, stabilizing the blood-brain barrier, and reducing cerebral edema through the modulation of pathways such as TLR4/NF-κB.
- Brand names
- Angong Niuhuang Pill
- Other names
- Early Angong Niuhuang PillANPAngong Niuhuang WanAGNHW
02
Targets
NF-κBMMP9 (Matrix metalloproteinase-9)TNFA (Tumor necrosis factor alpha (soluble))TLR4 (Toll-like receptor 4)IL1B (Interleukin-1 beta)
Beyond the preview
Go deeper on angong niuhuang wan.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on angong niuhuang wan.