Drug intelligence / Profile preview

Angusta

Development stage
Unknown
Lead developer
Norgine
Modality
Small Molecules
Administration
Oral, Sublingual
01

Overview

Angusta is a low-dose (25 µg) oral tablet formulation of misoprostol, a synthetic prostaglandin E1 (PGE1) analogue, developed specifically for the induction of labour. It was originally developed by the Danish pharmaceutical company Azanta and was subsequently acquired by Norgine in 2020. Angusta is indicated for the induction of labour in pregnant women from 37 weeks of gestation who have an unfavourable cervix. It acts as an agonist at prostaglandin EP2, EP3, and EP4 receptors, which promotes cervical ripening (softening and dilation) and stimulates uterine contractions to facilitate childbirth.

Brand names
Angusta
02

Targets

PTGER2 (Prostaglandin E2 receptor EP2)PTGER3 (Prostaglandin E2 receptor EP3 subtype)PTGER4 (Prostaglandin E2 receptor EP4 subtype)

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