Drug intelligence / Profile preview

Anhui Medical Univ. RIPK3 compound 32

Development stage
Preclinical
Lead developer
Anhui Medical University
01

Overview

Anhui Medical Univ. RIPK3 compound 32: sourced facts only. name: "Among these, compound 32 emerged as the most effective inhibitor, with strong inhibition of RIPK3 (IC50 = 27 nM) and necroptosis (EC50 = 0.45 μM)." [PMID:40398153]; target: "Among these, compound 32 emerged as the most effective inhibitor, with strong inhibition of RIPK3 (IC50 = 27 nM) and necroptosis (EC50 = 0.45 μM)." [PMID:40398153]; developer: "Anhui Province Key Laboratory of Inflammation and Immune Diseases, The Key Laboratory of Antiinflammatory and Immune Medicine, Ministry of Education, School of Pharmacy, Anhui Medical University, Hefei, 230032, Anhui Province, PR China." [PMID:40398153]; stage: "In an IMQ-induced mouse model of psoriasis, compound 32 significantly alleviates skin inflammation, scaling, and hyperkeratosis, without inducing notable toxicity." [PMID:40398153]

02

Targets

RIPK3

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