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Drug intelligence / Profile preview
anitocabtagene autoleucel
- Development stage
- Phase 3
- Lead developer
- Gilead Sciences
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies, Gene Therapies
- Administration
- Intravenous
01
Overview
Anitocabtagene autoleucel is a BCMA-directed chimeric antigen receptor (CAR) T-cell therapy developed for the treatment of relapsed or refractory multiple myeloma. It consists of autologous T cells genetically modified ex vivo to express a D-domain CAR that specifically targets B-cell maturation antigen (BCMA), using a CD8 hinge and transmembrane region fused to 4-1BB and CD3ζ intracellular signaling domains. This design aims to provide high transduction efficiency, stable CAR expression, and minimize tonic signaling. The drug has demonstrated deep responses in clinical trials, with high objective response rates in heavily pretreated multiple myeloma patients. Anitocabtagene autoleucel is being jointly developed by Arcellx and Kite (a Gilead company), with manufacturing handled by Kite for late-stage trials[1][3][5][6][7].
- Brand names
- CART-ddBCMA
- Other names
- Anti B cell maturation antigen-receptor complex T cell therapy - ArcellxAnti BCMA directed ARC T cell therapy - ArcellxBCMA-targeted cell therapy - Arcellx
02
Targets
BCMA (B-cell maturation antigen)
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