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anlotinib + cisplatin + pemetrexed
- Development stage
- Phase 2
- Lead developer
- Chia Tai-Tianqing Pharmaceutical Group
- Modality
- Classical Binding Small Molecules → Small Molecules, Covalent Small Molecules → Small Molecules, Nucleic Acid-Directed Small Molecules → Small Molecules
- Administration
- Oral, Intravenous
01
Overview
Anlotinib is an oral small molecule multi-target tyrosine kinase inhibitor that inhibits angiogenesis and tumor proliferation by targeting vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor (PDGFR), fibroblast growth factor receptor (FGFR), and c-Kit. Cisplatin is a platinum-based chemotherapy agent that forms DNA crosslinks, inhibiting DNA replication and transcription. Pemetrexed is an antifolate antimetabolite that disrupts folate-dependent metabolic processes essential for cell replication. The combination of these three drugs has been investigated as a first-line regimen for advanced non-squamous non-small cell lung cancer (NSCLC) in patients without EGFR/ALK mutations, showing promising antitumor activity and manageable toxicity[1][2][3].
- Other names
- anlotinib/cisplatin/pemetrexedanlotinib with cisplatin and pemetrexed
02
Targets
DNADHFR (Dihydrofolate reductase)FGFR1 (Fibroblast growth factor receptor 1)GART (GAR transformylase)PDGFRB (Platelet-derived growth factor receptor beta)TS (Thymidylate synthase)VEGFR-1 (Vascular endothelial growth factor receptor 1)VEGFR2 (Vascular endothelial growth factor receptor 2)VEGFR4 (Vascular endothelial growth factor Receptor-3)KIT (c-KIT proto-oncogene receptor tyrosine kinase)FGFR (FGFR family)
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