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anlotinib + cyclophosphamide + vinorelbine
- Development stage
- Phase 2
- Lead developer
- Sun Yat-sen University
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Anlotinib + cyclophosphamide + vinorelbine is a combination chemotherapy and targeted therapy regimen being investigated by Sun Yat-sen University for the maintenance treatment of children with intermediate-high risk rhabdomyosarcoma. Anlotinib is a multi-targeted tyrosine kinase inhibitor that suppresses tumor angiogenesis and growth by inhibiting VEGFR1/2/3, FGFR1-4, PDGFRα/β, and c-Kit. Cyclophosphamide is an alkylating agent that cross-links DNA, preventing cell replication. Vinorelbine is a semi-synthetic vinca alkaloid that binds to tubulin, inhibiting microtubule assembly and inducing mitotic arrest. This oral regimen is evaluated in Phase II trials to improve long-term survival and response duration in pediatric patients following standard therapy.
- Other names
- Anlotinib+Cyclophosphamide+Vinorelbine
02
Targets
DNAFGFR1 (Fibroblast growth factor receptor 1)PDGFRB (Platelet-derived growth factor receptor beta)TUBB (Tubulin (alpha and beta subunits))VEGFR-1 (Vascular endothelial growth factor receptor 1)VEGFR2 (Vascular endothelial growth factor receptor 2)VEGFR4 (Vascular endothelial growth factor Receptor-3)KIT (c-KIT proto-oncogene receptor tyrosine kinase)FGFR2 (Keratinocyte growth factor receptor)FGFR3 (Fibroblast growth factor receptor 3)FGFR4 (Fibroblast growth factor receptor 4)PDGFRA (Platelet-derived growth factor receptor alpha)
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